The Seven Sisters Generating Station is a hydroelectric generating station located on the Winnipeg River, in eastern Manitoba near Seven Sisters Falls, Manitoba.

The reservoir is called Natalie Lake and is used for recreational boating and fishing.

It is the largest generating station on the Winnipeg River.

[1] Construction of the station by the Winnipeg Electric Company (now a part of Manitoba Hydro) started in 1929, with first power in 1931, producing 75 megawatts from three vertical turbine-generator units.

When first constructed, operating staff lived in the townsite (Seven Sisters, Manitoba), but the plant was automated in the 1970s and put under remote control, requiring a much smaller on-site staff.