Throughout the draft process, Griffin had private workouts and visits with multiple teams, including the Pittsburgh Steelers, Tennessee Titans, Detroit Lions, Indianapolis Colts, San Francisco 49ers, Seattle Seahawks, Dallas Cowboys, and Philadelphia Eagles.

Throughout training camp, Griffin competed against Jeremy Lane, DeShawn Shead, and Neiko Thorpe for the starting cornerback job.

Head coach Pete Carroll named Griffin the fourth cornerback on the depth chart behind Richard Sherman, Jeremy Lane, and Neiko Thorpe.

Griffin played the majority of the game after Jeremy Lane was ejected in the first quarter after allegedly throwing a punch at Packers wide receiver Davante Adams.

[30] On October 8, 2017, Griffin made his first career start after Jeremy Lane was inactive after suffering a groin injury during their Week 4 victory over the Colts.

[32] The following week, Griffin earned his second consecutive start with Lane still inactive and recorded three solo tackles and a season-high three pass deflections in Seattle's 24–7 victory at the New York Giants.

[33] After Lane returned from injury, head coach Pete Carroll stated Griffin would remain the starting cornerback entering Week 8.

[34] On November 20, 2017, Griffin recorded one solo tackle before leaving the Seahawks' 34–31 loss to the Atlanta Falcons in the first quarter after suffering a concussion.

During a Week 16 matchup at the Cowboys, Griffin collected five combined tackles and made his first career sack on Dak Prescott as the Seahawks defeated them 21–12.

[36] On December 31, 2017, Griffin recorded six solo tackles, deflected two passes, and made his first career interception during their 26–24 loss to the Arizona Cardinals.

[1] On September 17, 2018, Griffin notched two interceptions and three pass deflections against Chicago Bears quarterback Mitchell Trubisky in a 17–24 road loss at Soldier Field.

In Week 15 against the Washington Football Team, Griffin intercepted a pass thrown by Dwayne Haskins during the 20–15 win, setting a single season career high with his third.