[13][2] Between 1999 and 2003, she had a recurring role on the SAB TV sitcom Yes Boss, alongside Aasif Sheikh, Rakesh Bedi, Kavita Kapoor, and Delnaaz Irani.

[19] In April 2005, she starred in a leading role alongside Archana Puran Singh and Seema Biswas in the English language independent film Minus One (2005), directed by Renny Mascarenhas.

In January 2013, she was appointed as the managing director for Brihans Natural Products,[24][2] becoming the first woman in her family to head a business under their group of companies.

[26] In September 2015, she was an award presenter at the Shraavan Queen beauty pageant held in Mumbai and hosted by the Maharashtra Times.

[31] In October 2018, she was an award presenter alongside Amyra Dastur for the Mrs. Stylista beauty pageant hosted by the magazine.

She has also leveraged her Bollywood background to secure celebrity endorsements and film sponsorships for the company's brands.

[39] In August 2021, she was one of the women in business featured on the cover of Femina's Independence Day issue of their Pune edition.

[42] In June 2023, Agashe alongside Jonita Gandhi and Shilpa Rao presented the Grazia Millennial Award for Breakthrough Performer of the Year to Sanya Malhotra.