She attended a school taught by Irish nuns—she had a gift for languages and drama, which motivated her dream of a career in Hollywood.
[8] She served for seven years as UNAIDS regional director for Eastern and Southern Africa, where she provided leadership and political advocacy for the AIDS response in 21 African countries.
Global HIV Prevention Coalition was born out of the need to address the gap and rise in new infections, despite success in treatment and care.
[12] After being defeated in primary elections of the Botswana Democratic Party (BDP) in Palapye, she was dismissed from the Cabinet on April 1, 2008, when Ian Khama took office as President.
Tlou has worked with grassroots women's organisations and national campaigns to increase AIDS awareness in Botswana.
She has also done a great deal of work in reducing the stigma of AIDS and helping HIV positive people cope with their lives.