In 1991, he earned his PhD in Molecular Biophysics, from the Indian Institute of Science, Bangalore working under the supervision of M. Vijayan.

In September 2001, he moved to Centre for DNA Fingerprinting and Diagnostics in Hyderabad as a senior staff scientist.

[4][5] He has served on many national and international committees including the scientific advisory committee of the International Centre for Genetic Engineering and Biotechnology, Trieste, Italy; Management Council of the Tata Institute of Fundamental Research (TIFR), Mumbai, Member of the Council of Indian Institute of Science, Bangalore; member of the Management Councils of the Solapur University and the Savitribai Phule Pune University; member of the Governing Body of the Indo-French Centre for Promotion of Advanced Research (CEFIPRA), etc.

He is also the National President of Vijnana Bharati, a large voluntary science movement in India with Swadeshi spirit.

[citation needed] Prior to moving to Delhi in October 2018 to handle Ministry of Science and Technology portfolios, Mande served on many advisory committees in Government Departments.