[1] In the 1998–99 season with the Toronto St. Michael's Majors and the Barrie Colts of the Ontario Hockey League, Keefe scored over 100 points, and was named the OHL Rookie of the Year, over Jason Spezza and Brad Boyes.

[2] Keefe was then selected 47th overall, in the 1999 NHL Entry Draft as the second choice of the Tampa Bay Lightning and subsequently signed a three-year contract with the team.

Upon winning the OHL championship, Keefe, as captain of the Colts, infamously refused to shake the hand of league commissioner David Branch, telling him, "this must burn your ass.

"[5] At the Memorial Cup, the team walked out on a customary banquet, threatened members of the opposing Rimouski Oceanic, and refused to shake hands with Branch, also serving as Canadian Hockey League president, during pregame ceremonies.

[citation needed] Keefe purchased the Pembroke Lumber Kings, a struggling Junior A franchise in the Central Canada Hockey League, in July 2003.

[10] After a knee injury effectively ended his career in the 2004–05 AHL season, Keefe began to assist Lumber Kings head coach and general manager Kevin Abrams.

During the 2005–06 season, Keefe's then agent, David Frost, caused a wave of concern throughout the CJHL when he was found in an off limits area of an Ottawa arena.

[11][12] Keefe was named as head coach and general manager of the Lumber Kings on June 6, 2006, after Abrams was promoted to league commissioner.

[15] At the national championship-deciding Royal Bank Cup, the Lumber Kings lost to the Aurora Tigers in overtime of the semi-final to end their season.

[17] Midway through the 2012–13 CCHL season, Keefe announced that he was leaving the Lumber Kings to become the head coach of the Ontario Hockey League's Sault Ste.

[18] Keefe announced over Twitter on May 29, 2013, that he had sold the Pembroke Lumber Kings to former Calgary Flames player, and Eganville native Dale McTavish.

[22] In 2014–2015, the Greyhounds' revitalization was complete, and the team posted their greatest season in franchise history, topping the OHL with a 54–12–2 record thanks to a league-leading 342 goals scored.

[35] His younger brother, Adam, serves as head coach of the Belfast Giants of the Elite Ice Hockey League (EIHL).