Morrison was born in the South Bronx, New York City, the only daughter of Hortense, a homemaker, and Maurice Mitrani, a clothing manufacturer.

Morrison studied acting at Los Angeles City College and landed early film roles in Divorce American Style and How to Save a Marriage and Ruin Your Life.

[citation needed] From 1965 to 1967, she appeared four times as an American Indian, Linda Little Trees, in the television series Laredo (in the episodes "Yahoo", "Jinx", "No Bugles, One Drum", and "Split the Difference.

On August 3, 2017, co-creator Max Mutchnick announced to reporters that Morrison had been asked to reprise her role as Salazar on the show, but that she ultimately decided to retire completely from acting.

Although her last official acting role was a voiceover in the 2012 animated film Foodfight!, her final appearance as an actress was the 2016 election-themed webisode of Will & Grace.