[2] Peyton moved to the University of California, Irvine, where she worked on tissue engineering for the cardiovascular system in the research group of Andy Putnam.
[5][7] In 2011, Peyton joined the University of Massachusetts Amherst,[5] where she established a research program in the design and application of biomaterials.
[citation needed] Peyton investigated the fundamental mechanisms that underpin metastasis through the engineering of carefully controlled environments.
[9] Specifically, the three-dimensional tumour spheroids allow Peyton to precisely control and study the response of biological tissue to cancer cells and therapies.
[14] Peyton is involved with various initiatives to support LGBTQIA+ researchers at the University of Massachusetts Amherst and Biomedical Engineering Society, and was encouraged to do so by Naomi Chesler.