Sheree L. Sample-Hughes (born September 13, 1977) is an American politician who since 2015 has served as a member of the Maryland House of Delegates representing legislative district 37A in Dorchester and Wicomico Counties on the Eastern Shore, centered around Salisbury.

[12] In May 2023, following votes against several bills backed by Democratic leaders of the legislature, Jones said she would not renominate Sample-Hughes as speaker pro tempore during the 2024 legislative session, instead nominating delegate Dana Stein.

[18] She has expressed concerns about Eastern Shore counties' ability to implement the Blueprint for Maryland's Future reforms,[19] which she supports.

Sample-Hughes supported an unsuccessful amendment to the bill that would have allowed Eastern Shore school systems to continue using a private company for contracting its virtual education services.

[19] In February 2025, during debate on a bill that would require public schools to teach age-appropriate health education that included sexual orientation, family, and gender identity courses, Sample-Hughes was the only Democrat to vote for an amendment proposed by state delegate April Rose that would have allowed parents to opt their students out of gender and sexual orientation health education courses.

[31] During the 2015 legislative session, Sample-Hughes supported a bill to require private employers to provide employees with accrued sick leave.

[33] In 2020, Speaker Adrienne A. Jones appointed Sample-Hughes to the Work Group to Address Police Reform and Accountability in Maryland.

[34] The work group released its recommendations in October, which included repealing the state's Law Enforcement Officers' Bill of Rights and regulating the types of force that police could use during arrests.

[36] In October 2020, Sample-Hughes expressed concern with proposed budget cuts by Governor Larry Hogan that would've required the Maryland State Police to close one of its helicopter bases, which she feared would affect public health and safety on the Eastern Shore.

[5] In 2019, Sample-Hughes said she supported legislation to establish the Maryland Truth and Reconciliation Commission to document racially motivated lynchings in the state's history.

[39] Sample-Hughes later attended a rally in June 2021 to call for the removal of the Talbot Boys statue in Easton, which was the last Confederate monument on public land in Maryland.

[40] During the 2022 legislative session, Sample-Hughes voted against the Trans Health Equity Act, which requires the state's Medicaid program to cover gender-affirming treatment.