It begins in the Gainer Industrial area, where Argyll Road and 82 (Whyte) Avenue merge, before it intersects 50 Street.

The freeway passes underneath a railway overpass to a diamond interchange at 50 Street, after which the speed limit increases to 100 km/h (62 mph) and the road passes between the Morris Industrial area to the north and the Weir Industrial area to the south.

[5] Between 34 Street and Anthony Henday Drive, the boundary between Edmonton and Strathcona County follows the southern edge of Sherwood Park Freeway's right of way.

A high capacity, two-lane, semi-directional flyover carries traffic eastbound on Sherwood Park Freeway to northbound Anthony Henday Drive.

[10] Between Anthony Henday Drive and 17 Street, Sherwood Park Freeway carried approximately 40,000 vehicles per day in 2019, with heavy westbound volume in the morning peak hours and eastbound in the afternoon as commuters travel to and from the primarily residential community of Sherwood Park.

In the early 1900s, Wye Road followed the alignment of present-day 76 Avenue out of Edmonton to the east, en route to North Cooking Lake.

[10][5] Extensive upgrades to the eastern end of the freeway were finished in 2016 as part of a project completing the final northeast segment of the Anthony Henday Drive ring road.

[5] Work to rehabilitate the 50 Street bridge was also completed in 2016, extending the structure's surface life for an additional 10–15 years.