Shickshinny Creek (historically known as Shickohinna) is a tributary of the Susquehanna River in the Wyoming Valley in Luzerne County, Pennsylvania, in the United States.

The creek was historically polluted by culm near its mouth, but agriculture was the main industry in the watershed in the early 1900s.

Shickshinny Creek begins in a valley in Ross Township, northwest of Sylvan Lake.

It flows south for a few miles, crossing State Route 4024 and passing through two ponds.

At the southeastern end of Shickshinny Lake, the creek flows southeast for a few miles in a valley, crossing State Route 4007.

It then receives the tributary Reyburn Creek from the left and turns south, passing through the village of Koonsville and crossing Pennsylvania Route 239.

The creek flows through Shickshinny and crosses US Route 11 before reaching its confluence with the Susquehanna River.

[1] Shickshinny Creek joins the Susquehanna River 172.34 miles (277.35 km) upriver of its mouth.

[6] Upstream of one of its unnamed tributaries, the peak annual discharge of Shickshinny Creek has a 10 percent chance of reaching 650 cubic feet per second (18 m3/s).

The Pocono Beds are found at the same level as the creek slightly north of Shickshinny.

This rock formation consists of 200 feet (61 m) of gray sandstone and brownish sandy shales.

[10] In its lower reaches, the surficial geology in the vicinity of Shickshinny Creek consists of urban land highly disrupted by cut and fill, alluvium, alluvial terrace, fill, Wisconsinan Ice-Contact Stratified Drift containing stratified sand and gravel, Wisconsinan Ice-Contact Delta containing sand and gravel, Wisconsinan Bouldery Till (a glacial or resedimented till containing boulders, and bedrock consisting of sandstone and shale.

In its upper reaches, the creek is almost entirely dominated by Wisconsinan Till, bedrock, and some lakes.

[11] The watershed of the tributary Little Shickshinny Creek is located in the Wyoming Coal Basin.

[6] The mouth of the creek is in the United States Geological Survey quadrangle of Shickshinny.

During the largest flood in Union Township, which occurred in June 1972, the creek's floodwaters reached a depth of 2 feet (0.61 m) above McKendree Road in Koonsville.

[6] Shickshinny Creek was entered into the Geographic Names Information System on August 2, 1979.

[15] The first sawmill in Union Township, Luzerne County was built by Isaac Benscotter in 1802.

A masonry arch bridge carrying Glen Ave over the creek is 32.2 feet (9.8 m) long.

A concrete tee beam bridge carrying Pennsylvania Route 239 over the creek was constructed in 1925.

A bridge of the same type, but carrying State Route 4007, was built in Union Township in 1940.

A concrete tee beam bridge carrying that road over the creek was built in 1965.

[7] In 1996, 3,000 US gallons (11,000 L) of oil leaked from a pipe into Shickshinny Creek, but there was no major environmental damage.

[23] Wild trout naturally reproduce in Shickshinny Creek from its headwaters downstream to its mouth.

[24] The tributary Little Shickshinny Creek is listed on the Columbia County Natural Areas Inventory.