It was serialized in Media Factory's Comic Cune magazine from January 2019 to November 2023 and compiled into five tankōbon volumes.

Shimeji Simulation follows Shijima Tsukishima, a former hikikomori who decides to attend high school after spending two years in her closet.

Later, at school, Shijima is approached by Majime Yamashita, a girl with a fried egg on her own head, which she says she was born with.

[6] Jacob Parker-Dalton of Otaquest calls Shimeji Simulation a continuation of the imaginativeness of Girls' Last Tour, and compares the dour/dashing dynamic between Shijima and Majime to Chito and Yuuri in a May 2020 review.

[10] Matthew England of CBR, meanwhile, ranks it as number eight on their list of 5 Manga That Need An Anime Adaptation (& 5 That You Didn't Know Already Have One).