Considered a great beauty, Bo-Me was the favorite queen of Minkhaung I.
In August 1425, Bo-Me engineered the death of Thihathu by getting Le Than Bwa of Onbaung to assassinate the king.
She might have married the successor, eight-year-old Min Hla.
[note 1] Three months later, she poisoned the boy king and put her lover Prince Min Nyo on the Ava throne, and became the chief queen.
Thado of Mohnyin, who subsequently made Bo-Me a junior queen.