The Shire of Murrindindi is a local government area in the Hume region of Victoria, Australia, located in the north-east part of the state.

[1] It includes the towns of Alexandra, Buxton, Eildon, Flowerdale, Kinglake, Marysville, Molesworth, Strath Creek, Taggerty, Yarck and Yea.

[2] The Shire is governed by the Murrindindi Shire Council; its seat of local government and administrative centre is located at the council headquarters in Alexandra, it also has service centres located in Kinglake and Yea.

Parts of Murrindindi were badly affected by the 2009 Victorian bushfires, notably the towns of Marysville and Kinglake.

The Lake Mountain ski resort is an unincorporated area near the southern border of the shire, which creates a small exclave.