The Shire of Talbot and Clunes was a local government area about 160 kilometres (99 mi) northwest of Melbourne, the state capital of Victoria, Australia.

The shire covered an area of 541.31 square kilometres (209.0 sq mi), and existed from 1915 until 1994.

What became the Shire of Talbot and Clunes had its origins in several different local authorities during the 1850s gold rush: After the passage of the Local Government Amendment Act 1914, it was found that Talbot Borough did not meet the criteria for a borough, as its rateable income was below £300 per annum, so it was absorbed by Talbot Shire on 1 October 1915.

On 31 May 1965, an Order in Council united the Borough of Clunes with the Shire of Talbot, to create the new shire of Talbot and Clunes.

[3] Talbot and Clunes was divided into four ridings, each of which elected three councillors: * Council seat.