Shirley is a town in Piscataquis County, Maine, United States.

There were 248 housing units at an average density of 4.7 per square mile (1.8/km2).

36.2% of all households were made up of individuals, and 8.6% had someone living alone who was 65 years of age or older.

There were 189 housing units at an average density of 3.6 per square mile (1.4/km2).

23.5% of all households were made up of individuals, and 12.3% had someone living alone who was 65 years of age or older.

About 3.0% of families and 3.2% of the population were below the poverty line, including none of those under the age of eighteen and 17.6% of those 65 or over.