Shoolery's rule

Shoolery's rule, which is named after James Nelson Shoolery, is a good approximation of the chemical shift δ of methylene groups in proton nuclear magnetic resonance.

We can calculate shift of the CH2 protons in a A–CH2–B structure using the formula where 0.23 ppm is the chemical shift of methane and the empirical adjustments S are based on the identities of the A and B groups: Shoolery's rule is a particular instance of a general class of rules of the form with two substituents on methylene resulting in two parameters

{\displaystyle S_{A}}

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