In 1962, Saint Joseph's Hospital was founded by the Felician Sisters and was built by General Development Corporation for the Catholic Church.
[4] In early August 2004, Bon Secours announced that it would sell St. Joseph's Hospital to Health Management Associates.
[4] In 2005, Health Management Associates renamed St. Joseph's Hospital to Peace River Regional Medical Center.
[14][15] After Hurricane Ian hit Florida in late September 2022, ShorePoint Health Port Charlotte was the only hospital that was open in a 30-mile radius.
The hospital's patients were moved by ambulance to Physicians Regional Healthcare System in Naples.