The oldest sister, Anna Chai Chuen (Michelle Yim), deals with all the administrative management of the clinic.

The second sister, obstetrician Anita Chai Sam (Annie Liu), has high expectations of all people and situations.

In addition to the three siblings there is retired surgeon, oldest brother-in-law (Paul Chun); the accomplished plastic surgeon who is heads over heels for the second sister; the undercover pretty nurse (Bernice Liu); and the next generation family physicians and clinic staff.

The daily battle of wits in the clinic between the sisters Anna and Anita leaves little brother Andy stuck in the middle with a headache.

In the early years, oldest sister Anita was forced to give up her doctor career and become a nurse to look after the family.