St. Anthony's Shrine, the "Church on Arch Street," is a center for Roman Catholic ministry in Boston, Massachusetts directed by the Franciscan friars of Holy Name Province.

[1] The Shrine has served the residents and workers of Boston since its completion in 1955, the community is driven by its dedication to the mission of "welcoming all people through prayer and outreach."

The Archbishop of Boston donated his former mansion in Brookline to them in 1927, which they then converted into St. Francis Friary, a retreat house for laymen which opened the following year.

In 1944, shortly after being appointed archbishop, Richard Cushing suggested that the friars open a chapel of ease in the downtown area of the city.

The final stage of construction of the permanent chapel was begun with a groundbreaking ceremony in October 1952 which was presided over by Cushing and the civil officials of the city.

St. Francis House has since created its own board of directors and is a separate non-profit, but the friars and the Shrine have still remained connected with the people and the work there.