Si Sakhon (Thai: ศรีสาคร, pronounced [sǐː sǎː.kʰɔ̄ːn]) is a district (amphoe) of Narathiwat province, southern Thailand.

Originally Tambon Sa Ko was a part of the Rueso district, but the development division of the Thai military settled in the area from 1963–1974, thus developing the infrastructure of Tambon Sa Ko.

The interior ministry subsequently created Si Sakhon Minor District (king amphoe) consisting of the two tambons, Sako and Tamayung, on 23 September 1974.

[2][3] The name Si Sakhon refers to the Sai Buri River, which flows through the middle of the district.

The district is divided into six sub-districts (tambons), which are further subdivided into 39 villages (mubans).