Sick was created in 1960 by comic-book writer-artist Joe Simon, who also edited the title until the late 1960s.
Its contributors included Mad regulars Angelo Torres and Jack Davis, as well as Howard Cruse, Arnold Drake, Ernie Schroeder, Washington correspondent Jim Atkins, and B.K.
Its art director from 1961 until his death in 1967 was the noted comic-book artist Bob Powell.
Financed by Teddy Epstein and packaged by industry legend Joe Simon, the magazine was built on the more tasteless, politically incorrect humor dispensed by stand-up comics like the controversial Lenny Bruce.
The comedian is said to have bought 100 copies of any issue of Sick featuring excerpts on his routines that he then mailed to prospective clients.