He was named to the High School Sports Report Statewide All-State team and selected Offensive Player of the Year.

[18] In Week 15, against the Chicago Bears, Rice injured his knee, causing him to miss the final two games.

[19][20] The next season, Rice was named a starter with the Vikings new wide receiver acquisition Bernard Berrian.

When he returned, most of his playing time was when the Vikings were in the red zone as he would lose his starting job to Bobby Wade.

Rice won his starting job back, and showed chemistry with new quarterback Brett Favre.

[25] On November 18, 2009, Rice was named the NFC Offensive Player of the Week, the first time he received that award.

On Monday, August 23, 2010, three weeks into the next season's training camp, he decided to go through with the surgery and was unable to play with the Vikings until November.

[32] Rice underwent a "pick" procedure similar to microfracture knee surgery to repair joint cartilage damage.

Doctors poked holes in the hip bone, making it bleed to generate cells that would reconstitute themselves as replacement fibrocartilage to fill the damaged gap.

[38] Rice went on to have a role in the Vikings' late-season victory over the Buffalo Bills, with 105 receiving yards and two touchdowns, and before sustaining a concussion during Philadelphia Eagles game.

[43] After the lifting of the NFL lockout, Rice agreed to terms on a five-year, $41 million contract with the Seattle Seahawks.

[45] He was reunited in Seattle with offensive coordinator Darrell Bevell and quarterback Tarvaris Jackson, a member of the Vikings during Rice's tenure there.

[48] On October 14, 2012, in Week 6, Rice caught the game-winning touchdown from a 46-yard pass from rookie quarterback Russell Wilson to beat the New England Patriots by a score of 24–23.

[50] On December 2, in Week 13, Rice caught the game-winning touchdown from Russell Wilson in overtime, as the Seahawks edged past the Chicago Bears 23–17 at Soldier Field; he caught six passes for 99 yards and the one touchdown, keeping the Seahawks in contention for a wild-card berth with a 7–5 record.

[55] Without Rice, the Seahawks would win Super Bowl XLVIII after defeating the Denver Broncos by a score of 43–8.

[58] On July 23, 2014, Rice announced his retirement from professional football due to multiple concussions throughout his career.