Resulting in a victory for Macedon, it ended the 31st Dynasty of Egypt, which functioned as a satrapy under the Achaemenid Persian Empire.

Alexander succeeded in breaching the walls of Gaza by utilizing the engines that he had employed earlier that year, during the siege of Tyre brought by Hephaestion.

[6] The fortress was located on an eminence, on the edge of a desert from which the surrounding area could be easily controlled, including the main road from Assyria to Egypt.

[6] It is also likely that he was aware of Alexander's intention to secure absolute control over the Mediterranean coast before mounting an invasion of the Persian mainland.

[13][14] As a result of the siege, Alexander was allowed to proceed south into Egypt securely, without his line of communications being threatened from the North by Batis from Gaza.