The siege was a failure, and the determined resistance of the French gave more time for Francis I of France to gather strength against Charles V. The French offensive in Spanish territory in the summer of 1521 ended in failure; the uprising of the Kingdom of Navarre, that passed under Hispanic control in 1512, forced Marshal de Foix to retreat to avoid being cut off from his supply lines.
Following the Field of the Cloth of Gold, Henry VIII of England and his minister Thomas Wolsey made an alliance with the young emperor.
The Duke of Bouillon had been making incursions into Flanders for several weeks when Imperial force invaded northern France on 20 August.
The letters informed the king that Mézières was abundantly supplied and well defended, that it could withstand a long siege, and aid need not be sent.
Nassau-Sickingen then ravaged the east part of Picardy by crossing the Meuse, pillaging and destroying the villages along the Sormonne in the Ardennes, before returning to Hainaut.