In 1559, Kenshin was pushed once again by Uesugi Norimasa to take control of the Kantō back from the Hōjō, and in 1560 he was able to comply.

In August of the same year, he put southern Echigo under control of a five-man council for broad mobilization, as well formed a small investigative council for any kind of unrest.

Uesugi Kenshin was at the height of his campaign against the Hōjō clan, as he captured several of their castles.

The Uesugi breached the defenses, and burned the castle town.

This came as the result of a lack of adequate supplies, and the reappearance of Takeda Shingen, Kenshin's long-time rival, who was threatening his territories.