In 1956, the late Cardinal Rufino Santos of the Archbishop of Manila invited the Dominican sisters to establish an academy for the education of local children.

In 1957, Saint Catherine Academy opened during the tenure of the late Mother Natividad Pilapil O.P., the Superior General of the Congregation.

(Latin: Ordinis Praedicatorum; English: Order of Preachers) building houses kindergarten 1 and 2, grade one pupils, and faculty rooms for their teachers.

The San Lorenzo Ruiz Hall is named for the Filipino martyred during persecution of Japanese Christians under the 17th-century Tokugawa Shogunate.

The gymnasium offers student facilities, including the St. Catherine Covered Court, an Semi-Olympic sized swimming pool, and the St. Martin Sports Complex.