The school was founded in June 1958 by the Mission Siaters in response to the need to provide Catholic education to the children who live in the vicinity of UST.

In June 2010, DSM made the decision to adapt the Alternative Learning System Program to assist out-of-school youths who desire to finish Basic Education.

[needs update] The school was founded in June 1958 by the Religious Missionaries of St. Dominic in response to the need to provide Catholic education to the children who live in the vicinity of UST, particularly its employees.

Catalina Girls' Dormitory and Sr. Esperanza Melgar, OP the secretary general, a two-room structure was constituted in May 1958.

In 1963, this structure was demolished to give way to the construction of a two-storey concrete building that can accommodate pupils from kindergarten to grade IV.

DS continues to improve its facilities, and its academic program inspired by St. Dominic and guided by their shared mission of promoting the integral formation of the youths.

In School Year 2006-2007, DSM started operations for the secondary level in the newly constructed seven-story building.

In June 2010, DSM made the decision to adapt the Alternative Learning System Program to assist out-of-school youths who desire to finish Basic Education.

By June 2015, the school was also able to support a number of Grade 7 Students through the ESC Voucher Program sponsored by the national government and the Fund for Assistance to Private Education (FAPE).