It serves as the midpoint and terminating station of most trains on the Central Tuscan Railway, with current services mostly running either to Chiusi-Chianciano Terme or Empoli, a large percentage continuing to Florence SMN.

In 1906, a faster line was proposed, running down to Buonconvento before travelling alongside the Ombrone river to Monte Antico.

There are various sidings around the station, notably alongside the bay, where rolling stock for the historic steam and diesel Trenonatura services along the Asciano-Monte Antico line is sometimes kept.

All trains that serve the station are operated by Trenitalia, and most are of the regionale type, with destinations most commonly being Florence SMN, Empoli, Grosseto and Chiusi-Chianciano Terme.

[1] Historic Trenonatura steam and diesel trains that operate through the Val d'Orcia on the Asciano-Monte Antico line start their journeys from Siena on selected days of the year, first using the Siena-Grosseto line as far as Monte Antico before turning around and travelling towards Asciano.