The Sierra de Santa Cruz is a small mountain range in eastern Guatemala.

The mountain range has a south-west to north-east orientation, and is approximately 55 km long and 13 km wide.

[1] Its highest peaks have an altitude of approximately 1100 m (15°40′52″N 89°19′37″W / 15.68122°N 89.32692°W / 15.68122; -89.32692).

Craugastor trachydermus, a species of frog in the family Craugastoridae, is endemic to Guatemala and only known from its type locality, Xiacam in the Sierra de Santa Cruz.

This Guatemala location article is a stub.