The Sierra los Huicholes is a mountain range in western Mexico.

The mountains are named for the Huichol, a people who live in the range and in the river valleys west and east of it.

The Sierra los Huicholes runs roughly north and south, dividing the basin of the Bolaños River to the east from that of the Huaynamota and its tributaries the Atengo (or Chapalagana) and Camotlán to the west.

Both the Bolaños and the Huaynamota empty into the Río Grande de Santiago, and the canyon of the Grande de Santiago defines the southern end of the Sierra.

[1] The mountains are home to some of the last remaining old growth pine–oak and pine forests in the Sierra Madre Occidental, and are also home to many limited-range and threatened species, including the thick-billed parrot (Rhynchopsitta pachyrhyncha).