[12] HOPEworldwide managed the hospital and volunteers such as internist Cameron Gifford and nurse Cathy Pingoy initially provided its staffing.

[14] Construction of a $300,000 annex to the hospital's main building began in January 2002 to expand its community AIDS program, and treatments of diabetes, dermatology, and hypertension.

Gary Jacques, the hospital's director from 2003–2007, noted that when he started, most key staff members were expatriates, but now Cambodians had been trained to fill those roles, and the number of women in directorial positions had grown.

[19] According to its website in November 2022, the hospital's mission was "to provide affordable, quality healthcare to those living in Cambodia in poverty, while training the nation's top clinicians to further serve the Cambodian population.

With over 200 Cambodians on staff, the hospital's laboratory, nursing, pharmacy, radiology, and surgical departments were the main training sites for Cambodia's university medical students.