AgF has relatively few niche applications; it has been employed as a fluorination and desilylation reagent in organic synthesis and in aqueous solution as a topical caries treatment in dentistry.

[7][8]: 3736 [9] At ambient temperature and pressure, silver(I) fluoride exists as the polymorph AgF-I, which adopts a cubic crystal system with space group Fm3m in the Hermann–Mauguin notation.

[15]: 286 [5]: 150  With this and the material's solubility in water considered, it is unsurprising that it has found little application in photography but may have been one of the salts used by Levi Hill in his "heliochromy",[16] although a US patent for an experimental AgF-based method was granted in 1970.

[19]: 562  Due to its high solubility in water and organic solvents, it is a convenient source of fluoride ions, and can be used to fluorinate alkyl halides under mild conditions.

[25]: 430 It is possible to coat a silicon surface with a uniform silver microlayer (0.1 to 1 μm thickness) by passing AgF vapour over it at 60–800 °C.

[26] The relevant reaction is: Multiple studies have shown silver(I) fluoride to be an effective anti-caries agent, although the mechanism is the subject of current research.

[27] Treatment is typically by the "atraumatic" method, in which 40% by mass aqueous silver(I) fluoride solution is applied to carious leisons, followed by sealing of the dentine with glass ionomer cement.