Simon was a son of Mamia II Gurieli, Prince of Guria, by his wife Tinatin Jaqeli.
[1] On his accession, Simon quickly came into conflict with Levan II Dadiani of Mingrelia, whose sister Mariam he had married in 1621.
[1][2] Having lost his throne, sight, and family, Simon, once freed from captivity, retired to Jerusalem and became a monk there.
[1] Simon was still alive and residing in Georgia in 1672, when the Frenchman Jean Chardin was travelling in the Caucasus.
According to Chardin, Mariam hosted her seasoned and frail ex-husband at the border with Imereti and gave him some means to survive.