Simona left her family home at the age of 17 to travel North America and Africa before moving to London to pursue her acting career.
Simona first worked in theatre in London, in productions like Much Ado About Nothing, As You Like It, and Queen of Spades.
This led to a string of independent films including a major role in Lycanthropy (2006), alongside George Calil and David Bradley,[1] and then to television work on such shows as The IT Crowd, Life Begins, Footballers' Wives, Bad Girls and Casanova's Love Letters.
[citation needed] Moving onto international projects, Brhlikova landed the role of the villainess Kisscut in Gallowwalker starring opposite Wesley Snipes, and Maddoff: Made off with America about the infamous Ponzi schemer Bernie, playing mastermind "Ursula aka Mrs X".
In 2013, Simona can be seen adding a touch of mystery and sophistication to Danny Dyer's Vendetta.