After the San Martino commission he worked on the city's Palazzo Reale, previously partly abandoned but then being restored by Juan de Vega, the Spanish viceroy of the island.
These works were continued by his successors Juan de la Cerda, Carlo d'Aragona Tagliavia and especially Marco Antonio Colonna who moved into the Palazzo from 24 April 1577 after a triumphal entry into the city and remained there until 1584.
The work drew on Raphael's Christ Falling on the Way to Calvary, then hanging in Santa Maria dello Spasimo in Palermo and now in the Museo del Prado in Madrid.
De Wobreck also produced another work on the subject for the church of Santa Maria Maddalena in Ciminna, whilst in 1585 he produced three works - a Madonna of the Rosary with the Mysteries (now in the Pinacoteca del Castello di Grifeo in Partanna), Adoration of the Magi for Tre Re Orientali church in Catania (now in that city's Museo Civico in Castello Ursino) and Flagellation (Palermo Diocesan Museum) De Wobreck's reputation also attracted several pupils such as Giulio Mosca and Domenico Nore to his studio.
He was a close friend of Giovanni Paolo Fondulli, a painter from Cremona who spent a few years in Palermo, producing an Annunciation for its church of Santa Maria di Porto Salvo.