Isnello (Sicilian: Isneḍḍu) is a comune (municipality) in the Metropolitan City of Palermo in the Italian region of Sicily, located about 70 kilometres (43 mi) southeast of Palermo.

Isnello borders the following municipalities: Castelbuono, Cefalù, Collesano, Gratteri, Petralia Sottana, Polizzi Generosa, Scillato.

Former New York City mayor Vincent R. Impellitteri was born in Isnello in 1900.

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