Castelvetrano (Sicilian: Castiḍḍuvitranu) is a town and comune in the province of Trapani, Sicily, southern Italy.

By the 15th century, records exist of a federation of local cities which includes Castelvetrano.

The economy is based predominantly on farming, with the cultivation of vines and olive trees being the main focus.

The center of Castelvetrano consists of three linked squares and many monuments can be found within these areas.

The main square is Piazza Tagliavia, which is adorned with many fine buildings including the town's principal church, the Chiesa Madre, which in its present form dates back to the sixteenth century.