See text Simplexvirus is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Alphaherpesvirinae.

Diseases associated with this genus include skin vesicles or mucosal ulcers, rarely encephalitis, and meningitis.

[1][2] The following 17 species are assigned to the genus in ICTV 2022:[2] Viruses in Simplexvirus are enveloped, with icosahedral, spherical to pleomorphic, and round geometries, and T=16 symmetry.

Entry into the host cell is achieved by attachment of the viral gB, gC, gD, and gH proteins to host receptors, which mediates endocytosis.

The virus exits the host cell by nuclear egress, budding, and microtubular outwards viral transport.