It was first inhabited about 800 CE by peoples of the Coastal Coles Creek culture.

The inhabitants traded their local marine resources, including such locally produced items as shells and shell beads, to peoples located further up the Lower Mississippi River valley.

During the second occupation period trade expanded, and the local ceramics show connections to Lower Mississippi Valley peoples and Plaquemine peoples located near modern-day Barataria Bay and to peoples of the Pensacola culture, located on the upper Gulf Coast near what is modern-day Biloxi, Mississippi.

This period, between 1100 and 1450 CE, was during the initial phases of occupation and expansion of the Bottle Creek site, the major center of the Pensacola culture.

The next phase sees increasing contact with Mississipianized Plaquemine peoples from as far up the Mississippi River as the Baton Rouge area, as well as continued interaction with the Mississippian Pensacola peoples.