[2] Sindh University is noted for its research in literature, natural sciences, philosophy, and Sindhology.

[4] In 2018, the university was ranked eighth in "General Category" by the Higher Education Commission of Pakistan.

[6] A formal academic centre was therefore needed for Sindh and under Constitutional Act 27, titled University of Sindh, a resolution was passed by the provincial Legislative Assembly which founded the new university in Karachi, the national capital at the time.

From independence in 1947 until 1955, Hyderabad was declared as the capital of Sindh and University operations were relocated from Karachi to Hyderabad in 1951,[8] where it formally began to function as a teaching institution striving to fulfil its charter and its mission to disseminate knowledge.

With the sudden departmentalised growth of the university's organisational structure, a better equipped campus was desired.

Colleges affiliated with the university primarily enforce curricular requirements and host examinations for degree-awarding status.

The university's teaching departments, institutes and centres offer programmes culminating in a four-year bachelor's (honours) degree in general and basic disciplines under arts and humanities studies, while a four-year bachelor's degree is offered under the faculty of natural sciences.

The Fatima Jinah Gymnasium provides game and sport facilities exclusively for women.

The Institute of Sindhology building, depicting the cultural heritage of Sindh, adorns the entrance to the campus from the national highway leading to Karachi.

Formerly deserted patches of hilly tract have now been converted into tree lined roads and green pasture.

It has hosted international conferences, symposiums and seminars on science and education and on specialized scientific themes.

The museum and art galleries of the Institute of Sindhology attract many visitors from other parts of Pakistan and the world.