In November 1999, then-Minister for Health Lim Hng Kiang announced that Singapore's public healthcare institutions would be reorganised into two delivery networks, or clusters.

[8] SNEC adopts a multi-subspecialty approach to treating complex eye conditions, as such disorders require strategic management with other disciplines.

To meet growing healthcare needs, the new NCCS building opened in 2023 with increased capacity and expanded facilities dedicated to cancer care, rehabilitation, research and education.

The new building not only includes facilities for outpatient clinics and non-invasive testing, but also has operating theatres and an invasive cardiac catheterisation laboratory.

With over 9,000 inpatient admissions every year, the 186-bed specialty centre for cardiovascular disease in Singapore offers treatments from preventive to rehabilitative cardiac services.

Multidisciplinary sub-speciality services are available through the NDC's Centres for Corrective Jaw Surgery, Maxillofacial Rehabilitation and Facial Pain.

The establishment of the NNI in 1999 resulted in the transfer of the departments of Neurology and Neurosurgery from Tan Tock Seng Hospital (TTSH) to form a new clinical service.

Personal particulars of 1.5 million SingHealth patients and records of medicines dispensed to 160,000 outpatients, were stolen in a cyberattack occurring between 27 June and 4 July 2018.

Information relating to the names, National Registration Identity Card numbers, addresses, dates of birth, and race and gender of patients who visited specialist outpatient clinics and polyclinics between 1 May 2015 and 4 July 2018 was maliciously accessed and copied.