[2] The presence of a single transverse palmar crease has no medical significance.

In its non-symptomatic form, it is more common among Asians and Native Americans than among other populations, and in some families, there is a tendency to inherit the condition unilaterally; that is, on one hand, only.

The presence of a single transverse palmar has been associated with several abnormal medical conditions—that is, it is found at a higher than 1.5% frequency, but in all of these conditions, many do not have this crease.

[5] It is also sometimes found on the hands of the affected side of patients with Poland syndrome and craniosynostosis.

A 1971 study refutes the hypothesis that the phenomenon is caused by fetal hand movement: the appearance of the crease occurs around the second month of gestation before the digital movement phase in the womb begins.