Between 1927 and 1935, Hedin led an international Sino-Swedish Expedition which investigated the meteorological, topographic and prehistoric situation in Mongolia, the Gobi Desert and Xinjiang.
He gave archaeologists, astronomers, botanists, geographers, geologists, meteorologists and zoologists from Sweden, Germany and China an opportunity to participate in the expedition and carry out research in their areas of specialty.
For example, the discovery of specific deposits of iron, manganese, oil, coal and gold reserves was of great economic relevance for China.
One aspect of the geography of central Asia which intensively occupied Hedin for decades was what he called the “wandering lake” Lop Nur.
After the lake dried out in 1971 as a consequence of irrigation activities, the above-mentioned transportation link enabled the People's Republic of China to construct a nuclear weapon test site at Lop Nur.
[6] Some of Ma Zhongying's Tungan (Chinese speaking Muslim) troops attacked Hedin's expedition by shooting at their vehicles.
[7] For the return trip, Hedin selected the southern Silk Road route via Hotan to Xi'an, where the expedition arrived on 7 February 1935.
He celebrated his 70th birthday on 19 February 1935 in the presence of 250 members of the Kuomintang government, to whom he reported interesting facts about the Sino-Swedish Expedition.