Sint Anna ter Muiden is a small city in the province of Zeeland, Netherlands.

It is located on the westernmost point of the Netherlands (excluding the kingdom's other countries and its special municipalities).

Sint Anna ter Muiden was granted city rights in 1242 by the counts of Flanders, Thomas II of Savoy and Jeanne of Flanders.

This makes it today the second smallest place in the Netherlands that bears this traditional designation (after Staverden with just 40 inhabitants).

Sint Anna ter Muiden was a separate municipality until 1880, when it was merged with Sluis.