The street runs south from Nieuwmarkt square to the Sint Antoniesluis sluice gates, where it continues as the Jodenbreestraat.
In the early 17th century, the street was popular with immigrants and artists such as the painter Rembrandt, who lived there from 1631 to 1635, at the home of art dealer Hendrick van Uylenburgh.
Other painters who lived in the street, near the Guild of Saint Luke in the former Sint Anthoniespoort, include Pieter Isaacsz, Esaias Boursse, who lived next door to Rembrandt, Nicolaes Eliaszoon Pickenoy, Cornelis van der Voort, Roelant Savery, Pieter Lastman (in whose workshop Rembrandt served as apprentice), Adriaen van Nieulandt, Pieter Codde, Willem Kick, Justus and Johannes Vingboons, and their father David Vinckboons.
[2] During World War II, many residents were taken away to the Nazi concentration camps and the neighbourhood was left practically deserted.
New houses were built along the existing Sint Antoniesbreestraat, and the Huis de Pinto, which had become a symbol of the movement to save the neighbourhood, was renovated and now serves as public library.