This species was originally identified in Hawaii (Kihei, Maui) and Papua New Guinea, and has a wide distribution throughout the western and central Pacific Ocean.

[2][3] Siphopteron quadrispinosum is a relatively small species of sea slug, growing to a maximum length of 5 mm (0.20 in).

Papua New Guinean specimens have the colouration of the siphon continuing along the posterior shield.

In Hawaiian populations, the parapodia have a white margin and the orange-red colouration along the posterior shield is absent.

[3] Siphopteron quadrispinosum lives at depths of 6 to 27 metres (20 to 89 ft) on sand beds, and among Halimeda kanaloana, a species of macroalgae.