Sir Edmund Isham, 6th Baronet (18 December 1690 – 15 December 1772) was a Member of Parliament for several successive terms during the reigns of Kings George II and George III of Great Britain.

He was educated at Rugby School and Wadham College, Oxford and embarked on a legal career, becoming an advocate in Doctors' Commons (1724) and a judge advocate in the Court of Admiralty (1731–41).

He unexpectedly became Baronet of Lamport on 5 March 1737 when his older brother Justinian died young.

He was easily elected a few weeks later on 31 March 1737 to his brother's seat in Parliament as the Tory Member of Parliament for Northamptonshire, and ran unopposed each successive term after that for the rest of his life.

There is a painting of Sir Edmund by Thomas Hudson hanging at Lamport Hall.