Born at Heston, he was the son of Sir Francis Blake, 2nd Baronet and his wife, the daughter of Alexander Douglas.
Blake owned estates at Twizell Castle, Tillmouth House, Seghill and Duddo, which he sold for £45000 in 1823.
He married Jane, daughter of William Neale, in 1827 but had no legitimate children, and the baronetcy became extinct upon his death.
His illegitimate son Frederick Blake (1835–1909) suffered severe sunstroke while serving as an army officer and was confined to a mental asylum in 1873.
His father granted him a life interest in property at Seghill and also bequeathed Helen, the widow of his brother Robert Dudley Blake (1776–1860).