The twelfth Baronet represented Galway Borough in the British House of Commons.
He was the great-grandson of Robert Blake, Mayor of Galway in 1547, brother of the first Baronet of Menlough (see above).
Sir Francis's mother was Sarah, eldest daughter of Sir Francis Blake, of Cogges, Oxfordshire, who married Elizabeth (née Carr) of Ford Castle, Northumberland, and purchased Twizell Castle, also in Northumberland, in 1685.
The heir presumptive is Jonathan Luttrell Blake (born 1953), a kinsman of the present holder.
The heir apparent to the baronetcy is Francis Julian Blake (born 1971), eldest son of the 3rd Baronet.